![]() ![]() After the intravenous administration of 1 × 10 5 UC-MSCs, we confirmed a significant improvement in the UC-MSC group in a negative geotaxis test at 1 week after birth and a rotarod treadmill test at 5 months old. The ameroid constrictors were attached to bilateral ovarian/uterine arteries on the 17th day of pregnancy to induce chronic mild ischemia, which led to FGR with over 20% bodyweight reduction. To create the FGR rat model, we used ameroid constrictors that had titanium on the outer wall and were composed of C-shaped casein with a notch and center hole inside that gradually narrowed upon absorbing water. We aimed to develop a new FGR rat model with a gradual restrictive load of uterus/placental blood flow and to evaluate the treatment effect of the administration of umbilical cord-derived mesenchymal stromal cells (UC-MSCs). Therefore, the development of treatments is an urgent task. It causes various disorders, including neurodevelopmental disabilities due to chronic hypoxia, circulatory failure, and malnutrition via the placenta, and there is no established treatment. 6Department of Food and Nutrition, Faculty of Home Economics, Kyoto Women’s University, Kyoto, Japanįetal growth restriction (FGR) is a major complication of prenatal ischemic/hypoxic exposure and affects 5%–10% of pregnancies.5Department of Cell Processing and Transfusion, Institute of Medical Science, University of Tokyo, Tokyo, Japan.4Clinical Research Center, Division of Biostatistics and Data Science, Medical and Dental University, Tokyo, Japan. ![]() 3Faculty of Pharmaceutical Sciences, Sanyo-Onoda City University, Yamaguchi, Japan.2Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.1Division of Neonatology, Center for Maternal-Neonatal Care, Nagoya University Hospital, Nagoya, Japan.Yuma Kitase 1,2, Yoshiaki Sato 1*, Sakiko Arai 1,2, Atsuto Onoda 1,3, Kazuto Ueda 1, Shoji Go 1, Haruka Mimatsu 1,2, Mahboba Jabary 1,2, Toshihiko Suzuki 1, Miharu Ito 1, Akiko Saito 1, Akihiro Hirakawa 4, Takeo Mukai 5, Tokiko Nagamura-Inoue 5, Yoshiyuki Takahashi 2, Masahiro Tsuji 6 and Masahiro Hayakawa 1 ![]()
0 Comments
Leave a Reply. |